5/13/22

How does Apoquel (Oclacitinib) Treat Food Allergy in Dogs?

Apoquel can be used to relieve some symptoms of food allergy in dogs, i.e. itching, swelling, and skin irritations. 

An elimination diet helps to figure out the root cause of food allergies in dogs. Removing that specific food from your dog's diet is the only solution to getting rid of food allergies in dogs permanently.

how-does-Apoquel-oclacitinib-treat-food-allergy-in-dogs


If your dog is suffering from atopic dermatitis, Apoquel can help
. This oral tablet targets the underlying cause of irritation and controls itching in dogs within 24 hours. Apoquel is suitable for both short and long-term treatment. 

It is sourced directly from the manufacturer and is 100% genuine. Listed below are the main uses for Apoquel.

Apoquel Effectiveness for Treating Food Allergy in Dogs


The effectiveness of Apoquel Oclacitininib maleate tablets for treating food allergy in dogs has been evaluated in two clinical trials. 

The study was performed in dogs aged 6 to 14 months. The high-dose, 3X, and 5X treatment groups were given 1.8 mg/kg of oclacitinib maleate tablets twice a day for up to 14 days. In a masked study, dogs in both groups were given the same dosage of Apoquel, and the high-dose, 5X, group received a daily dose of 1.8 mg/kg of oclacitinib maleate. 

However, the high-dose treatment group was not affected by the oclacitinib. The tablets should be stored at a temperature

In this study, dogs with suspected food allergies were put on a hypoallergenic diet from day zero. The dogs were tested for allergies using intradermal allergen tests and concomitant allergen-specific immunotherapy for 6 months prior to study enrolment. 

All participants were required to adhere to the protocol throughout the study. It is important to note that the protocol must be followed until the end of the study.

The study involved 436 dogs. All dogs were randomized according to their breed and age. The dosages were four to sixty-three milligrams. 

The dogs were monitored for up to 32 days after the study concluded. Apoquel Oclacitinib maleate tablets have been shown to be effective for treating food allergies in dogs.

In the study, the researchers included client-owned dogs with moderate-to-severe pruritus and suspected allergic dermatitis. They were randomized to receive either oclacitinib or an excipient-matched placebo. 

The dogs were evaluated using an enhanced 10-cm visual analog scale or by a veterinarian. The dogs enrolled in the trial were allowed to stay on treatment for up to 28 days.

Results of the study showed that the drug reduced serum globulin and lymphocyte levels. However, oclacitinib caused an increase in cholesterol and lipase in the dogs. A few dogs were withdrawn from the study due to severe adverse effects. 

Of the 179 dogs that received oclacitinib maleate tablets, 11 experienced abnormal health events. In one of these dogs, diarrhoea and vomiting were so severe that the dog had to discontinue treatment.

Safety


While the efficacy of Apoquel Oclacitininib maleate tablets for the treatment of food allergies in dogs is promising, the medication is not without side effects. 

These tablets should be given in the recommended dosage and intervals as directed on the label. Taking the medication with food will also ease the gastrointestinal side effects. Other less common side effects include an increased susceptibility to infections. 

These infections include respiratory and urinary tract infections, although they are rare. In case of fever or shortness of breath, contact your veterinarian right away. Also, inform your veterinarian of any other medications your dog is taking.

Since Apoquel is not a cure for food allergies, it is used to treat chronic, persistent skin conditions. Although it can cure some skin conditions, it is typically prescribed as a lifelong treatment. 

And it can have long-term side effects. Since it can cause chaos in the immune system, it's a good idea to use Apoquel only for severe cases.

Although the safety of Apoquel Oclacitininib maleate tablets for the treatment of food allergy in dogs remains a concern, clinical trials show that it has a better efficacy profile than placebo. 

A randomized clinical trial with client-owned dogs was conducted in the USA. Twenty-four general practitioners with a special interest in veterinary dermatology participated, including two veterinary dermatology specialists.

The drug is not a cure for the underlying cause of atopic dermatitis in dogs. Instead, it forces the immune system to make up for the lack of treatment by preventing the kinase pathway from working properly. 

Without Apoquel, the immune system can go into a complete state of chaos. If the medication is suddenly stopped, the dog's dermatitis will get worse, and the condition may recur.

Another potential side effect of Apoquel is that it reduces the dog's white blood cells. It can lead to lethargy, high cholesterol, and extreme weight loss. It can also worsen preexisting cancers. 

Furthermore, Apoquel reduces the immune system's ability to fight cancer, so it can increase the risk of these side effects.

Dosing


In this phase III trial, the Apoquel Oclacitinip maleate tablets were given to 121 client-owned dogs with atopic dermatitis. They were given two tablets twice a day for seven days. Percentage acceptance rates ranged from 89.9 to 93%, and did not differ significantly from placebo. 

However, no research has been conducted on how dosing compliance affects owner satisfaction or compliance with the treatment.

Apoquel is a drug that can effectively relieve the itching and inflammation caused by food allergies in dogs. It can be given in a single dose or as a continuous course of treatment for as long as seven days. 

It should be used only in dogs and should not be administered to bitches younger than 12 months of age or dogs with serious infections. The tablets should be given in 15-minute intervals and are effective for relieving the itching and inflammation caused by allergic dermatitis.

Dosing of Apoquel Oclacetinib maleate tablets for treating food allergy in dogs is based on the weight of the affected dog. 

For dogs suffering from allergic dermatitis, the dosage should not exceed 0.4 mg/kg body weight every day. For dogs with food allergies, it should be increased to 0.6 mg/kg daily.

Apoquel is FDA-approved for dogs who are at least 12 months of age. However, higher doses of Apoquel can cause demodicosis or pneumonia. 

Apoquel is not a good choice for young puppies because it is a JAK inhibitor and can lead to increased cholesterol and liver values. Apoquel also has potential to lead to weight gain and herpes zoster.

Dosing Apoquel Oclacitinid maleate tablets for treating food allergy in dogs was not associated with significant adverse reactions. The drug was well-absorbed, with a peak effect in less than one hour. Its clearance was hepatic. 

It was safe for dogs to receive the tablets as directed, but the safety and effectiveness of the medication is not fully understood.

Side Effects


This new allergy treatment works by blocking the immune system, which is what triggers the itch. Doing so prevents the body from fighting infection. Apoquel tablets, which are available by prescription, are available in three different doses and can be administered to dogs of any age or weight. 

Side effects of Apoquel may include vomiting, diarrhea, lethargy, and loss of appetite.

For Small Animals


The FDA-approved drug Apoquel is an oral tablet that treats severe skin conditions and itching in dogs. It is often prescribed for the treatment of atopic dermatitis, a serious skin disease with no known cure. 

Apoquel works by inhibiting Janus kinase pathways, which regulate the immune system. Apoquel may have side effects, and veterinarians discourage its use in small animals.

Apoquel is a relatively new allergy medicine that is approved by the FDA for dogs over 12 months old. It does have some risks, however, including increased incidence of Demodex mange and pneumonia in puppies. 

Also, this drug may be ineffective for dogs that have tumors. It is a JAK inhibitor, and as such can cause high cholesterol and liver values. It can also cause herpes zoster, liver damage, and weight gain.

The drug should be administered according to the manufacturer's recommendations and at the prescribed interval. The medication can also cause gastrointestinal side effects, which are easily alleviated by feeding it with food. 

Other side effects include increased susceptibility to infections, including respiratory and urinary tract infections. Skin infections are rare. 

However, fever and shortness of breath should be reported immediately to the veterinarian. It is important to disclose any other medications that may be affecting your dog's health.

Apoquel is an immunosuppressive drug approved for the treatment of chronic atopic dermatitis in dogs. It inhibits the JAK-1/STAT pathway to prevent the release of pro-inflammatory cytokines. 

This drug has good feedback from vets for treating dog psoriasis, eczema, and allergies. It works in a matter of hours after oral administration. Apoquel is a top choice for severe allergic dermatitis.

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