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The antiparasitic drug metronidazole is used to treat a variety of parasites. Its main target is dientamoeba fragilis, a gastrointestinal protozoan with widespread distribution. Metronidazole is used for both humans and dogs. 


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In addition to being a common cause of chronic gastrointestinal illnesses, dientamoeba fragilis also co-infects with Enterobius vermicularis. 

However, few studies have investigated the anti-parasitic effect of metronidazole on Dientamoeba fragilis. 

For example, in one randomized trial on humans, metronidazole was given to children with co-infection with E. vermicularis and the effect on parasite prevalence was assessed.

Side Effects and Adverse Reactions


The anti-parasitic metronidazole treatment can have harmful side effects. As a strong antibiotic, metronidazole kills good bacteria in the gut, which are essential for a healthy digestive system. 

Furthermore, it changes the bacterial community in the gut, which can result in an imbalanced microbiome. As a result, metronidazole can lead to gastrointestinal problems in dogs.

Metronidazole for Protozoan Infections in Dogs


Metronidazole is used to treat protozoal infections in dogs and cats, as well as anaerobic bacterial infections. 


This antibiotic also exhibits immune-modulating effects and can be prescribed in combination with other drugs. 

Moreover, it can also cause side effects in dogs, including neurological injury and liver damage. When used long-term, metronidazole can result in severe side effects, including paralysis of the legs.

Flagyl for Anaerobic Bacteria


Unlike metronidazole, Flagyl is an antibiotic used to treat anaerobic bacteria. Dogs can take Flagyl if they are suffering from an infection. 

Other uses for Flagyl include treating bacterial vaginosis. Its side effects include neurologic signs of overdose and gastrointestinal bleeding. 

Metronidazole Generic

Metronidazole is available as a generic or brand-name drug. This antiprotozoal drug is available in several forms, including oral tablets, creams, vaginal gel, and even an injectable medication. 

It is a popular choice in the treatment of many types of infections caused by bacteria, and is even used for vaginal infections in dogs. However, metronidazole may have limited activity against facultative anaerobes.

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