In this article, I will analyse the “Safety Analysis of Gabapentin and Apoquel for Dogs.”

I will also discuss some of the potential side effects of Gabapentin and its effectiveness in pain management and anxiety. 

Is it safe to administer Apoquel and Gabapentin together in dogs?

Yes, Apoquel and Gabapentin can be administered together for dogs –  as there is no known interaction between the two drugs.

However, it is important to speak to your VET about the best treatment plan for your dog.

Apoquel and Gabapentin can be given together in dogs – but be sure  the benefits overweigh the side effects and risks associated with these drugs.

Safety Analysis of Apoquel and Gabapentin for Dogs

The safety analysis of Apoquel and Gabapeptin for dogs indicates that both drugs may cause nausea and vomiting in dogs. However, they are not recommended to administer in dogs who have serious illnesses such as bacterial pneumonia. 



Safety of Apoquel 

Dogs suffering from pre-existing tumors should also avoid the use of Apoquel, as it may worsen the disease. Apoquel is safe to use in dogs with other drugs such as antibiotics and topical ointments for bacterial and fungal skin infections. 
Apoquel does not interfere with allergy tests and there are no reported drug interactions with other common medications.

Apoquel  Side Effects on Dogs:

The most common side effects of Apoquel for dogs are vomiting, diarrhea, lethargy, anorexia, and decreased appetite.

Other less-common Side Effects may include weight loss, skin infections, skin irritation, and an increase in drinking and/or urination.

As always – it is important to talk to your VET if you notice any of these side-effects – while your dog is given Apoquel.

Read also: Can Humans take Apoquel – Interactions and Side Effects of these Drug!

Safety of Gabapentin

Unlike a typical antidepressants –  Gabapentin does not have a direct anxiolytic effect. It may be a useful adjunct therapy for dogs suffering from chronic stress and anxiety. 

For this reason, gabapentin may be prescribed in combination with Prozac, a selective serotonin reuptake inhibitor, or Clomicalm, a tricyclic antidepressant.

Gabapentin Side Effects on Dogs:

In order to minimize the risk of side effects of Gabapentin for dog’s;  Veterinarians recommend that you give gabapentin orally.. 
Dosage is dependent on the type of condition your dog is suffering from, including chronic pain or seizures. 
Gabapentin is generally given every 8 to 12 hours. However, it can be given more often if your pet is experiencing more severe symptoms.Most dogs tolerate gabapentin well, but some dogs may experience sedation and ataxia. While these side effects are often mild and may not interfere with the treatment, they are common enough to require further evaluation. 

In some cases, an allergic reaction may occur, resulting in hives, swelling, difficulty breathing, and more serious symptoms. Before administering Gabapentin to your dog, tell your veterinarian of any other medications, supplements, and other health conditions that your pet may be taking. 
Be sure to keep a journal of your dog’s health, and inform your VET of any current medications, dosages, and administration schedules for other drugs and supplements.

Effectiveness of Gabapentin for Pain Management

A study on the effectiveness of gabapentin for pain management in dogs showed that this drug helped to reduce the  level of discomfort in older arthritic dogs. While gabapentin has fewer side-effects than other pain medications, some dogs may respond poorly to this treatment. 

It is always best to consult a VET when administering gabapentin to your dog. While gabapentin has gained popularity as a pain management medicine –  it was not initially developed to relieve pain.
The dosage of gabapentin for dogs is usually a 250-milligram per kilogram (mg/kg) tablet!

Gabapentin is admistered orally – three to four times daily. For the best effect, gabapentin should be administered in tablet form, as the liquid form is toxic to dogs.

Additionally, gabapentin may interact with certain medications, so it’s important to discuss your dog’s specific needs with your VET before starting gabapentin.

Ineffectiveness of Gabapentin for Anxiety

The Ineffectiveness of Gabapentin in the treatment of anxiety in dogs is due to itsImpotence in affecting the GABAergic neuronal system. The chemical analog of GABA has been used for decades now –  for its anxiety-fighting properties. 

Recent studies have suggested that gabapentin may not have the desired effect in reducing anxiety in dogs. Although gabapentin is not FDA-approved for canine use, it is often prescribed by vet’s to treat seizures and various types of pain.

Gabapentin is metabolized by the liver and kidneys and should be avoided in dogs with kidney or liver disease, pregnant or nursing dogs, or those who are allergic to certain medications.

Gabapentin can also cause some vitamin deficiencies, which may affect the nerve repair processes. While gabapentin does not have a direct anxiolytic effect, it has been shown to be useful in treating chronically stressed or anxious dogs.


There are no contraindications to giving Apoquel and Gabapentin together to dogs! Like almost any Drug also Apoquel and Gabapentin have potential side effects, and dogs with certain conditions should avoid them.

While gabapentin may not be very effective in treating anxiety in dogs – it has been shown to be useful in pain management and can be prescribed in combination with other medications.

Doctor Xeeshan

Doctor Xeeshan

I am Doctor Xeeshan, located in Lahore, Punjab, Pakistan. In this blog, I am providing authentic information about dog breeds, diseases, medications, etc.


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