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Yes, this medication may cause side effects including lethargy, tiredness, and fatigue. Read the following piece of article that explains how doxycycline causes lethargy in dogs?


While most side effects of doxycycline in dogs are minor, the medication can also cause stomach upset and vomiting. Although gastrointestinal upset is a minor side effect, severe cases of vomiting or diarrhea can be a sign of an allergic reaction.

Pregnant or Nursing Dogs 

If you suspect your dog is pregnant or is nursing, it is essential to tell your veterinarian. Thankfully, these side effects are rare and can be minimized by giving your dog the medication with food.

Common Side Effects of Doxycycline in Dogs

The most common side effects of doxycycline are diarrhea, vomiting, and lack of appetite. 

Although these effects are rare, you should take the medication with food to alleviate any nausea or vomiting. If your dog shows signs of liver disease, doxycycline may also cause an increase in the liver enzymes on blood work. 

If your dog develops lethargy after taking the drug, call your veterinarian right away.

What is Doxycycline and How it Causes Lethargy in Dogs?

Doxycycline in dogs is an antibiotic that works by entering the bacterial cell and blocking protein synthesis. Protein synthesis is essential to all living cells, but doxycycline is effective against bacteria and other pathogens that cause infections. 

It can work with other medications to treat different bacterial conditions in dogs. Your vet will decide the best dosage for your dog based on your dog’s specific condition.

If your veterinarian prescribes doxycycline to your dog, it’s important to follow his directions for proper dosage. 

Make sure you take the full course of the medicine prescribed by your vet and stick to it! That way, your pet won’t develop antibiotic-resistant bacteria and can’t relapse. And if your dog develops a new infection, it’s best to stop the antibiotic as soon as possible.

Alternative to Doxycycline for Dogs

Another medication that may reduce vomiting and diarrhea in dogs is Cerenia. This medication is used for a variety of different reasons, including separation anxiety and panic disorders

It can be given up to three times per day and doesn’t interact negatively with other medications. It’s safe to give Cerenia to a dog as long as it’s at least eight weeks old. Using Cerenia is not recommended for a dog under two months of age.


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