If you’re using Cefpodoxime proxetil medication for your dog urinary tract infection or for other bacterial infections and wanted to know, Does Cefpodoxime cause frequent urination in dogs?. Then you’re in the right place. Because in the following article, I would explain Simplicef (Cefpodoxime proxetil) side effects and adverse reactions in small animals including dogs and cats.  
Before I get started, it’s important to know, What is Simplicef used for in dogs?. Basically, it’s an FDA (Food and Drug Administration) approved veterinary antibiotic composition uses to treat infectious diseases caused by bacteria, in all small animals. Simplicef generic name is Cefpodoxime proxetil which belongs to cephalosporins, a class of antibiotic drugs, that kills bacteria by disrupting the bacterial cell walls.


It is used to treat all types of urinary tract infections (including kidney infection, bladder infection, urethra infection, urethral tubes infection), soft tissue infections, periodontal disease, wounds, abscesses, skin disorders (including folliculitis, staph infection, cellulitis, pyoderma,). It may also use to treat bacterial infections not described here.

Common Causes Behind Frequent Peeing

A urinary tract infection may be a problem for constant peeing in your dog. If a dog has a bladder infection, kidney stones, kidney disorders, ureters, or urethral infection, then antibiotics like Simplicef 100mg/200mg film-coated tablets (Cefpodoxime proxetil) are suggested to treat the bacterial infection in dogs. 
Recurrent urination helps the dog to discharge pus and debris from the body. Antibiotics do not increase urination but there may be some other problems which may cause constant urination in your pet like;
  • Hormonal Imbalance
  • Electrolytes Imbalance
  • Kidney’s disorder
  • Bladder Infection
  • Diabetes
  • Bladder Dysfunction
  • Tumors 
  • Kidney Stone
  •  Cancer
  • Urethral Ailment
  • Polyuria (abnormal production of a large amount of dilute urine)
A veterinarian may take X-ray of the bladder, kidney, or urinary tract to diagnose the main cause. He/She may also suggest some urine tests for your pet to precisely diagnose the problem. Persistent urination may be the signs of some chronic diseases like diabetes, cancer, kidney failure, etc. 

Simplicef Side Effects and Frequent Urination

Unnecessary usage of cephalosporin drugs may lead to antibiotic resistance in living organisms. Cefpodoxime medication may cause some serious adverse reactions in dogs and cats, especially those who are hypersensitive to any of its components or other cephalosporins like Cefixime, Cefepime, cefuroxime, etc. Also, consult your vet if your dog has any history of kidney disease, or an allergy to penicillin medication, cephalosporins, fluoroquinolones, or other any other antibiotic drug. Its side effects include some abdominal disorders like;
  • Vomiting
  • Gas
  • Abdominal Cramps
  • Abdominal Pain
  • Bloating
  • Gerd (Gastroesophageal Reflux Disease), the movement of stomach food towards the mouth
  • Increased Thirst
  • Diarrhea
  • Skin rashes, allergies
  • Inflammation or swelling of the face and other parts of the body
  • Blurred vision
  • Change in Behavior including consistent barking, aggressiveness, anxiety, etc.
Simplicef Cefpodoxime does not cause frequent urination in dogs, cats, or other animals. Consistent or recurrent urination in dogs may have more than one reason. It may be due to a urinary tract infection (more usual), diabetes, electrolyte imbalance, polyuria, etc. A vet may diagnose the main cause behind frequent urination in dogs after taking the X-ray, dog’s pee tests, and sometimes a few blood tests also help to precisely diagnose the problem.

Urinary Tract Infection Causes Frequent Urination

Kidneys, bladder, ureters, and urethra are the main components of a urinary tract. Your pet may have a urinary tract infection is the following symptoms are present. 
  • Pus discharge through urine
  • Smell in urine
  • Blood in the urine
  • Frequent urination
  • Increased thirst
  • Urinating a small volume of urine, but continuously
  • Your dog is getting weak or weaker
  • Loss of appetite or anorexia
  • Pain during or after peeing
It’s a common bacterial disease in dogs. Susceptible bacteria are present everywhere. A dog may get a urinary tract ailment through contaminated water, food, soil, etc. Commences bacteria (that live in dogs’ bodies without causing harm) can also develop a urinary tract disorder if the immune system of a dog gets suppressed (due to any reason).  

Strong antibiotics like enrofloxacin, Cefpodoxime proxetil, cephalexin are used to treat this kind of bacterial infection in dogs. These are the FDA approved drugs that are effective against a broad range of gram-positive and gram-negative bacteria.

If a dog is continuously urinating, it is chances that he has a urinary tract infection. But a Veterinarian may precisely diagnose the real problem behind the frequent urination in dogs after getting some tests. Simplicef film-coated tablets contain a third-generation, FDA approved, cephalosporin drug, Cefpodoxime proxetil composition. It treats all kinds of bacterial infections that affect different parts of the body.

Antibacterial medicines are used against over-population or over-growth of bacterial cells in the body. Their overdose may cause other chronic disorders like liver dysfunction, kidney failure. In the body. We don’t suggest or recommend any kind of medication. Consult your veterinarian before consuming any prescription drug. The article is for informative purposes only, which has provided a brief relationship between Simplicef medication and frequent urination in canine and feline.
Categories: Simplicef

Doctor Xeeshan

Doctor Xeeshan

I am Doctor Xeeshan, located in Lahore, Punjab, Pakistan. In this blog, I am providing authentic information about dog breeds, diseases, medications, etc.


Leave a Reply

Avatar placeholder

Your email address will not be published. Required fields are marked *

close X

Try The Best Rated Dog Food On Amazon

Ancient grains like grain sorghum, millet, quinoa and chia seed are naturally high in fiber and rich in protein. Unchanged for thousands of years, different grains provide various nutrients such as vitamins, minerals, antioxidants and omega fatty acids.