Traveling can be an exhilarating experience for humans, but it’s a different story altogether for our four-legged companions. The sights, sounds, and movements that accompany travel can trigger anxiety and motion sickness in dogs, turning a family trip into a stressful ordeal.

It’s no surprise that many pet owners turn to solutions to help their furry friends cope. Among these solutions, Benadryl has emerged as a popular choice. But how does Benadryl keep a dog calm during traveling?

Benadryl: Keeps a Dog Calm During Traveling

Short Answer: Benadryl, known generically as Diphenhydramine, is an antihistamine that can help keep dogs calm during traveling by exerting a sedative effect. It works by blocking histamine receptors in the brain, which not only reduces allergic reactions but also induces drowsiness. This sedative quality can alleviate travel-related anxiety and motion sickness in dogs, making their journey more comfortable.

Let’s dive into the world of canine travel anxiety and discover how this common medication might be the key to a peaceful journey.

Understanding Benadryl and Its Canine Connection

Benadryl, known generically as Diphenhydramine, is an antihistamine primarily used to relieve symptoms of allergy, hay fever, and the common cold in humans. However, its use has transcended species barriers, finding a place in veterinary medicine.

While not FDA-approved for veterinary use, veterinarians commonly recommend Benadryl for its sedative properties, making it a go-to remedy for pet owners seeking to alleviate their dog’s travel-related stress.

You may like reading about: Benadryl For Vertigo In Dogs

The Science Behind the Calm: How Benadryl Works in Dogs


Diphenhydramine, the active ingredient in Benadryl, works by blocking the H1 receptors in the brain. This action inhibits the uptake of histamine, a compound released during allergic reactions, leading to its well-known anti-allergic effects.

However, it’s the sedative effect that’s of interest when it comes to keeping dogs calm. By crossing the blood-brain barrier, Diphenhydramine induces drowsiness, which can significantly reduce anxiety and motion sickness in dogs during travel.

You may like reading about: Can Dogs Get Addicted To Benadryl?

Administering Benadryl: Dosage and Best Practices

Consulting a veterinarian before administering Benadryl is paramount. Though widely considered safe, each dog is unique, and factors such as breed, age, weight, and medical history must be taken into account.

General dosage guidelines suggest 1 mg of Benadryl per pound of body weight, administered 2-3 times daily. However, this is a broad recommendation, and the precise dosage should always be determined by a professional.

When it comes to administration, Benadryl is available in tablets, capsules, and liquid form. While the liquid form might seem convenient, it’s essential to check that it doesn’t contain alcohol or xylitol, as these substances can be harmful to dogs.

Tablets can be hidden in a treat or a pill pocket to make the process smoother.

You may like reading about: Does Benadryl Cause Constipation?

Navigating the Side Effects and Precautions of Benadryl Use


Even with its benefits, Benadryl isn’t without potential side effects. Drowsiness is the most common, but others include;

  • dry mouth
  • urinary retention
  • diarrhea
  • vomiting

More serious, yet rare, side effects include;

  • increased heart rate
  • agitation
  • an allergic reaction

Knowing your dog’s medical history and watching for signs of an adverse reaction are crucial. Should anything unusual occur, discontinue use and consult a veterinarian immediately.

Exploring Alternatives to Benadryl for Canine Calmness

While Benadryl is a handy tool, it’s not the only solution. Several alternatives can be equally effective in ensuring your dog’s comfort during travel. Behavioral training, for instance, can prepare your dog for the stimuli they’ll encounter during travel.

Gradually acclimating your dog to travel conditions, using positive reinforcement, can make a world of difference.

Other alternatives include calming treats, which often contain ingredients like chamomile or L-Theanine known for their soothing properties. Pheromone diffusers and collars are also popular, emitting calming chemicals that mimic those produced by mother dogs to soothe their puppies.

Conclusion: A Balanced Approach to Canine Travel Anxiety

Benadryl has earned its place in the pet owner’s travel kit, but it’s not a one-size-fits-all solution. It can be a godsend for dogs struggling with travel anxiety or motion sickness, but its use should be considered carefully. Consulting a veterinarian, knowing the correct dosage, and understanding the potential side effects are non-negotiable steps in responsible pet ownership.

As we embrace the joy of traveling with our furry friends, let’s remember that their comfort and safety are paramount. Whether through Benadryl, alternative remedies, or behavioral training, ensuring a calm and happy journey for our dogs is the ultimate act of love and care.

Frequently Asked Questions:

Is Benadryl safe for all dogs?

Benadryl is safe for most dogs, but not all. Breed, age, weight, and medical history play a vital role in determining its suitability. Always consult a vet first.

How long before traveling should I give my dog Benadryl?

It’s generally recommended to administer Benadryl 30 minutes to an hour before travel to allow it to take effect.

Can Benadryl be used for all types of travel (car, plane, etc.)?

Benadryl can be used for various travel modes, but each has its considerations. For instance, air travel might have specific regulations regarding sedatives.

How often can I give my dog Benadryl during a long trip?

Typically, Benadryl can be administered every 8-12 hours, but this can vary based on individual factors. Consult a vet for a tailored schedule.

Are there any long-term effects of using Benadryl for travel anxiety in dogs?

Occasional use of Benadryl for travel isn’t typically associated with long-term effects. However, regular or prolonged use should be discussed with a veterinarian.

Traveling with pets needn’t be a source of stress. Armed with knowledge, the right preparations, and a dose of care, you can make every journey with your dog a memorable and joyful one.

Always consult a licensed veterinarian before administering any medication to your pet.


Leave a Reply

Avatar placeholder

Your email address will not be published. Required fields are marked *

close X

Try The Best Rated Dog Food On Amazon

Ancient grains like grain sorghum, millet, quinoa and chia seed are naturally high in fiber and rich in protein. Unchanged for thousands of years, different grains provide various nutrients such as vitamins, minerals, antioxidants and omega fatty acids.