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Metronidazole mediation can take one to two weeks when used to treat diarrhea in dogs. A veterinarian may guide the exact duration of treatment for metronidazole. The duration of treatment depends on the severity of the infection and other complications (your pet is probably suffering).


Metronidazole is a widely used antibiotic for diarrhea, but it comes with side effects, including damaging the microbiome in your dog’s gut, which is a complex population of bacteria that aids in digestion and immune function. 

In addition to causing diarrhea, metronidazole also damages the gut’s pH levels and PH balance, so if metronidazole is used for long periods of time, your dog could still develop symptoms of diarrhea.

Metronidazole for Pregnant or Nursing Dogs

Metronidazole should not be given to pregnant or lactating dogs, as it may lead to Heinz body anemia. If your dog is nursing, it may be dangerous for her to take this medication. 

Although it is generally considered safe, it should not be given to dogs who are pregnant or nursing. Dogs with liver disease, neutropenia, or kidney disease should not take metronidazole.

How Much Metronidazole is Safe for Dogs?

Metronidazole can be given orally. The dose for most dogs is 10-30 milligrams per kilogram of body weight. Most dogs need to take metronidazole for 5-7 days. 

For severe cases, however, it may be necessary to give the antibiotic for up to a month. Your veterinarian will determine the best course of treatment for your dog’s specific condition.

Metronidazole for Chronic Diarrhea in Dogs

For severe cases of diarrhea, metronidazole may be necessary. A study by the National Institutes of Health demonstrated that metronidazole, an antibiotic commonly used for treating diarrhea in dogs, reduced the length of diarrhea by two days. 

In comparison, the control group required four days. Metronidazole is very effective against anaerobes, which are bacteria found in infected lungs and abscesses. It is also often prescribed for dental infections.

Researchers have studied the effects of metronidazole on the microbiome of healthy dogs. While metronidazole did improve gastrointestinal problems in dogs, it also caused changes in the microbiome. 

These changes continued after the drug was discontinued. The study authors recommended a cautious approach when treating dogs with diarrhea because the antibiotic affects the gut microbiome. The authors of this study also suggest using alternative therapies to treat the disease.

Side Effects and Adverse Reactions

Metronidazole is an antibacterial medication prescribed by veterinarians. It is also known as Flagyl. 

However, it has not been approved for use in canines by the FDA. The antibiotic disrupts the DNA of bacteria. This medication is not FDA-approved for use in dogs and must be used as prescribed by your veterinarian. However, you can buy metronidazole at a Chewy’s pharmacy.

Metronidazole for dogs is not FDA-approved, but most veterinarians consider it safe for use in dogs. 

The side effects of metronidazole include nervous system and gastrointestinal signs. Neurologic signs include ataxia, disorientation, stiffness, and bradycardia. The treatment should last at least 24 hours, depending on the severity of diarrhea and other conditions your pet is suffering from.

The dosage for metronidazole for dogs varies based on the condition and weight of the dog. The veterinarian will prescribe the right dosage for your dog. 

The first dose of metronidazole is twice the regular dosage. It should be given with food or a liquid that is meat-flavored. 

Both of these medications are bitter to your dog, and the liquid may cause spitting. It is also important to follow the veterinarian’s directions and not to give more than the recommended dose at once.


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