It’s very important to know that “Do Simplicef tablets belong to the sulfa group (sulfonamide group of drugs) or not”. Because a pet who has sulfonamide allergy may get serious side effects or adverse reactions by using Sulfa-drugs medication. The common adverse reactions may include swelling or inflammation of face or any other part of the body, skin rashes, difficulty in breathing, hot spots, etc. In the following article, I would answer all of your queries related to this topic. Enable GingerCannot connect to Ginger Check your internet connection
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Quick Answer: Is Cefpodoxime Proxetil A Sulfa Drug?


NO! simplicef (cefpodoxime proxetil) does not belong to sulfonamides. A dog with sulfa-allergy can use simplicef medication to treat a variety of bacterial diseases including skin infections, bladder infection, all types of soft tissue infections, etc. It’s an FDA (Food and Drug Authority) approved antibiotic drug used to kill a broad range of gram-negative as well as gram-positive bacteria that contains a cell wall. 

Because cefpodoxime proxetil is a cephalosporin drug. Cefixime, cefuroxime, cefprozil, cefepime are some common examples of cephalosporins. They kill or restrict the growth of bacteria by disrupting their cell walls. Hence, they stop bacteria from replication. Simplicef can be used against bacteria that have a cell wall. 

Antibiotics do not treat viral or parasitic infections. However, they can be used to treat secondary bacterial infections caused by viruses, parasites, and insect bites.

What is a Sulfa Group or Sulfonamide Group?

Chemical compounds that contain sulfur dioxide (SO2) attach with one or two amine groups (NH-H) are called sulfa-compounds and the drugs are known as sulfonamides. 


Here are some examples of sulfonamides contain a sulfa group in their chemical structures.

1. Co-trimoxazole or Sulfamethoxazole_Trimethoprim Combination (antibiotic_sulf drug)


2. Furosemide (diuratic_sulfonamide)


3. Gliclazide (diabetic_sulfonamide)


So you can see that all of the above chemical structures contain a sulfa group present in their structure. While you can also see that cefpodoxime proxetil chemical structure does not have a sulfonamide group. Below is the cefpodoxime proxetil chemical structure;



Simplicef chemical structure shows that there is no sulfa group present. So if someone is confused about a question, “Is Simplicef a Sulfa drug or Sulfonamide?” Then he/she must read the above article carefully. Because this article explains that Simplicef (cefpodoxime proxetil) does not belong to sulfonamide drugs. A dog or other animal with sulfonamide allergy can use this antibiotic drug to treat infectious diseases caused by bacteria (that contain a cell wall). 

Because this drug kills bacterial cells by disrupting their cell walls. Bacteria who lack a cell wall cannot be treated with this drug. So always consult a veterinarian before taking any kind of medication for your pets. However, cefpodoxime proxetil is a prescription drug that is only available on a registered veterinarian prescription only.

This chemical substance is safe to use in dogs, cats, and other small animals by the recommendation of a veterinarian. It’s recommended dose varies between 2.3milligrams to 4.5 milligrams per one pound (bodyweight). A vet may suggest the exact dosage plan for your pet after diagnosing the bacteria-type and the severity of an infection. If you have any further queries in your mind, feel free to ask. All you need is just comment below.
Categories: Simplicef

Doctor Xeeshan

Doctor Xeeshan

I am Doctor Xeeshan, located in Lahore, Punjab, Pakistan. In this blog, I am providing authentic information about dog breeds, diseases, medications, etc.


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