Simplicef 100mg and 200mg film-coated tablets are manufactured by Zoetis Pharmaceuticals Private Limited, a subsidiary of Pfizer Pharmaceuticals Company. The generic name for these tablets is Cefpodoxime Proxetil, a third-generation cephalosporin used to inhibit bacterial growth or eliminate bacteria.

There is widespread confusion among users who mistakenly believe Simplicef, an FDA-approved medicine, is a steroid.

In this brief article, I aim to address this frequently asked question from dog owners: “Is Simplicef (Cefpodoxime Proxetil) a steroid?

Is Simplicef A Steroid?

You may also like reading about: Can Simplicef For Dogs Be Crushed?

Quick Answer: Is Cefpodoxime a Steroid?

The answer is a resounding NO. Simplicef Tablets are not steroids; they are FDA-approved veterinary antibiotic drugs designed to treat a wide range of bacterial diseases in canines, felines, and other small animals.

Is Simplicef (Cefpodoxime) a Steroid? Quick Answer

Antibiotics and steroids are distinct categories with different functions. Cefpodoxime Proxetil, a third-generation cephalosporin, specifically targets infectious diseases caused by bacteria and does not address viral infections such as cold, flu, influenza, distemper, reovirus, etc.

The Difference Between Antibiotics and Steroids

Antibiotics like Cefpodoxime Proxetil:

Bacteria, microorganisms responsible for various infections across living organisms, are the target of antibiotics. The term “antibiotic” combines “anti” (against) and “biotics” (microorganisms, derived from “bios,” meaning life).

Simplicef’s generic Cefpodoxime Proxetil is utilized to treat urinary tract infections, including kidney and bladder infections, as well as infections in the ureters, urethra, periodontal areas, sore throats, ear/nose/eye infections, wounds, and soft tissue infections such as pyoderma, folliculitis, and cellulitis.

This antibiotic is effective against a broad spectrum of gram-positive and gram-negative bacteria, making it suitable for treating kennel cough in dogs and other bacterial diseases.

What are Steroids?


Steroids are biologically active substances with three primary types:

  1. Anabolic-androgenic steroids like testosterone
  2. Glucocorticoids like prednisolone, hydrocortisone
  3. Mineralocorticoids like vasopressin

Steroids, in general, do not address bacterial infections.

Glucocorticoids, such as cortisone, hydrocortisone, prednisolone, and methyl-prednisolone, are used to control allergic reactions in dogs. They may treat allergies, inflammation, swelling, asthma, bronchitis, arthritis, pain, and rashes.

As immunosuppressants, glucocorticoids suppress the immune system, offering immediate relief from symptoms associated with various ailments.

Steroids, including glucocorticoids, do not treat diseases independently but are often used in combination with other drugs, such as antibiotics, to address allergic reactions in the body.


This article clarifies that Simplicef is not a steroid but an antibiotic (antibacterial) drug containing Cefpodoxime Proxetil. This third-generation cephalosporin kills bacteria by disrupting bacterial cell wall synthesis, effectively treating bacterial infections in the dog’s body.

Steroids are fundamentally different from antibiotics; they are biologically active substances with three major types and do not treat bacterial infections like antibiotics. Glucocorticoids, such as prednisolone and cortisone, are immunosuppressants used to alleviate symptoms like pain, allergies, skin rashes, bronchitis, and asthma, often in conjunction with other medicines.

Other types of steroids, such as mineralocorticoids and anabolic-androgenic steroids, serve different purposes.

Categories: Simplicef

Doctor Xeeshan

Doctor Xeeshan

I am Doctor Xeeshan, located in Lahore, Punjab, Pakistan. In this blog, I am providing authentic information about dog breeds, diseases, medications, etc.


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