The following article provides a piece of brief information about the side effects of Simplicef 100mg/200mg tablets for dogs. A dog may face more than thirty types of unwanted consequences by using cefpodoxime proxetil medication. I have also provided the information on how to safely use cefpodoxime proxetil to treat infectious diseases in kittens, puppies, dogs, cats, in fact, all breeds of canine and feline.


Simplicef is an antibiotic drug used to treat a variety of bacterial diseases. It effectively treats infectious diseases caused by bacteria in dogs and cats. FDA (Food and Drug Administration) has approved it as an antibacterial composition for dog’s urinary tract infection, a stomach infection, intestinal infections, in a broad range of skin disorders including pyoderma, ear, nose, and eyes infections, cellulitis, folliculitis, and others not described here. 

Simplicef Without a Vet Prescription

All antibiotics are prescription drugs. They are not available without a registered veterinarian prescription. Unnecessary use of antibacterial drugs may cause antibiotic resistance in the body, which is harmful.  You may not get Simplicef (Cefpodoxime Proxetil) for your pet without a vet prescription at all.

How Does It Work?

Cefpodoxime proxetil is the active ingredient found in Simplicef (registered trademark of Zoetis pharmaceuticals company) 100mg/200mg tablets. It’s a broad-spectrum, third-generation highly effective cephalosporin (class of antibiotic), which kills bacterial by dismantling the cell wall of the bacterial cells, it also inhibits the growth of bacteria by stopping the process of bacterial cell wall synthesis.

Although, this antibacterial composition (Cefpodoxime Proxetil) has so many benefits of dogs and cats. As it treats a huge range of bacterial infections caused by gram-positive and gram-negative bacteria. It’s highly tolerated but maybe not suitable for some patients. All living organisms are different from each other and their body responds differently to drugs (an oral substance). So Simplicef may show some side effects or adverse reactions in some pets.

30+ Observed Side Effects Of Using Simplicef In Dogs

Every drug has some adverse reactions due to various reasons. If a dog’s body is hypersensitive to cephalosporins (cefpodoxime proxetil), it may show some unwanted consequences. If you mistakenly overdose the medicine, it may also show side effects. If you have seen any of the side effects or adverse reactions after using this antibiotic treatment, re-visit your doctor and consult about the situation.

Here is the list of common adverse reactions that were observed after using this drug.

Abdominal Adverse Reactions:

  1. Vomiting
  2. Gas
  3. Nausea
  4. Diarrhea
  5. Abdominal Cramps and Pain
  6. Constipation
  7. Loss of appetite
  8. Upset Stomach
  9. GERD (gastroesophageal reflux disease)
  10. Bloating
  11. Eat Slower

Allergic Reactions:

  • Skin itching/rashes
  • Shortness of breath
  • Cough
  • Hives or the inflammation on lips, jaws, etc
  • Dry skin

Mood Disorders/Behavioural Changes:

  • Drooling
  • Lethargy
  • Drowsiness
  • Quit digging
  • Quit peeing/urination
  • Nervousness
  • Quit Drinking
  • Irritated
  • Jerky
  • Sleepy
  • Aggressiveness
  • Anxious or Anxiety
  • Go crazy
  • Barking


  • Headache
  • Blood in urine
  • A dog feels more Thirsty/Increase the thirst/Drink more water
  • Urinate more/Pee/Increase urination
  • Bad Breath
  • Kidney failure (in severe cases or if a dog has a history of kidney disease)
  • Becomes Weak/Weaker
  • A dog looks Yellowish
above is the list of unwanted consequences a dog may suffer after using Cefpodoxime proxetil, a third-generation, strong antibiotic drug. But it’s just a list, as cefpodoxime proxetil is FDA approved veterinary antibiotic drug and is highly tolerable by the canine. More than 95% of canine don’t get any side effects or adverse reactions (when taken by the recommendation of a Vet). 


If a dog has a history of allergy to drugs like penicillin-type antibiotics like amoxicillin, ampicillin, etc or other cephalosporins like cefuroxime, cefixime, cefepime, etc. You must consult your veterinarian before taking cefpodoxime proxetil for the treatment of bacterial infections for your dog.



Simplicef cefpodoxime overdose may also play an important role in showing some kind of side effects. You should listen to the instructions carefully when a veterinary doctor prescribes a medication plan for your dog. Because cefpodoxime proxetil overdosage may result in diarrhea, upset stomach, abdominal pain, and other unwanted consequences.

Immediately discontinue the medicine if your dog has shown side effects like severe diarrhea, vomiting, nausea, upset stomach, abdominal pain, abdominal cramps, quit drinking, quit peeing, shortness of breath, gas, or blood in the urine and stool, etc. Revisit your veterinarian and apprise about the condition.
Categories: Simplicef

Doctor Xeeshan

Doctor Xeeshan

I am Doctor Xeeshan, located in Lahore, Punjab, Pakistan. In this blog, I am providing authentic information about dog breeds, diseases, medications, etc.


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