A dog may get a urinary tract infection due to bacteria, present in polluted air, contaminated water, soil, and food. When we talk about the urinary tract, it includes the bladder, kidneys, ureters, and urethra. Commences bacteria that are present in canine’ bodies without causing harm, they may also cause a UTI infection in dogs (when the immune system is suppressed), cats, and other pets. But the question is: “how Simplicef treat a urinary tract infection in dogs?”


Simplicef is a veterinary, FDA (Food and Drug Administration) approved antibacterial drug which contains Cefpodoxime proxetil, a chemical substance that kills a broad range of bacteria by dismantling their cell walls. These films-coated antibiotic tablets are present in 100mg and 200mg strengths. Cefpodoxime proxetil belongs to cephalosporins, a class of antibiotic drugs that contains the world’s best antibacterial compositions including cefuroxime, Cefixime, Cefepime, etc.

Common Symptoms Of Urinary Tract Infections In Dogs

A UTI disease in canine and feline is common. The dog may show rare to severe symptoms including blood in the urine. Below are some common symptoms that you may observe if your dog has developed a urinary tract ailment.

  • Increased thirst (if your dog is drinking more water than usual)
  • Increased urination or peeing
  • Pus or yellowish substance in the urine
  • Anorexia or the loss of appetite
  • Severe pain during urination
  • Dry mouth
  • Fever
  • Weakness
  • Kidney Stone
  • Yellowish color
  • Other including inflammation of the genital area

What Causes a UTI In Dogs?

More than 90% of urinary tract infections in dogs are caused by bacteria (single: bacterium). Different types of bacteria may be involved in developing an infection. Fungus (yeast), virus, and other pathogens may also cause a UTI in dogs. So it’s important to visit a veterinarian to diagnose the exact culprit.

A vet may take X-ray or advise some urine tests to exactly diagnose the cause of a urinary tract infection in pets. 

How Simplicef Treat a Urinary Tract Infection in Dogs?

Cefpodoxime proxetil present in this prescription drug is used to treat all types of bacterial infections including bladder infection, kidneys infection, ureters or urethra infection, soft tissue infections, wounds, periodontal disease including tooth infection, ear/nose/eye infections, abscesses and others that are not discussed here.

It may be used to all kinda infectious diseases in dogs where the bacteria are responsible. Cefpodoxime is a third-generation, strong, broad-spectrum antibacterial composition that is effective against a broad range of gram-positive as well as gram-negative bacteria. 

Simplicef 100mg/200mg Tablets Dosage for Dogs

Simplicef film-coated Tablets are available in 100mg and 200mg powers. A veterinarian may suggest the ideal dosage plan for your dog by diagnosing the bacterial type and observing the dog’s condition. However, cefpodoxime proxetil preparation is highly safe to use in dogs, as it’s an FDA approved veterinary antibiotic drug to treat bacterial diseases in small animals.

The recommended dose for Simplicef is 2.3mg/lb to 4.5mg/lb or 5mg/kg to 10mg/kg. It depends upon the situation and at what stage of infection you’re using the antibiotic treatment. You may comment below to find the exact dosage plan for your dog by its weight.

Recovery Time

It’s highly suggested to avoid antibiotics if they are not necessary because more often or unnecessary use of antibiotics may cause antibiotic resistance.  It is important for you to listen to your dog’s veterinarian instructions carefully to avoid overdose and other complications.

A vet may suggest cefpodoxime medication for a urinary tract infection for 7-14 days depending on the severity of illness. The antibiotic duration may be increased to a maximum of 30 days if it is necessary. 

By using Simplicef medication for a urinary tract infection or UTI in dogs, you will observe improvement within 3 days. If you don’t see any improvement or your dog’s condition gets worsens then it is advised to re-visit the veterinarian doctor and consult the situation again.

 Possible Adverse Reactions

Although, cefpodoxime proxetil is highly acceptable by the dog’s body. But it is not necessary that it’s suitable for all pets. Every individual is different from each other and their bodies react differently against an external substance or drug. Immediately discontinue the medication, if you see the following side effects of unwanted consequences by using this antibiotic treatment.

  • Severe vomiting
  • Diarrhea
  • Skin rashes
  • Itching
  • Swelling or inflammation on face/jaw
  • Reddish spots on the body
  • Nausea
  • Cough/Kennel Cough
  • Dry mouth/increased thirst
  • mood swings or behavior changes including barking, anxiety, or aggressiveness, etc.
Above are some side effects of using cefpodoxime proxetil in dogs. If you observe any of them, it is advised to discontinue the medication and re-visit your vet about the condition. 

What Increases The Chances Of Adverse Reactions?

Simplicef is highly contraindicated for dogs, cats, and other small animals whose body is hypersensitive to cephalosporins, penicillin, or any of the ingredients present in Simpilcef 100mg/200mg tablets. You should not overdose the medication, if you ever forget to give the dose, never give a double dose

Cefpodoxime tablets should be taken 12 hourly. It may interact with other drugs like If your pet is taking any other medication, food supplements, or vitamins and minerals including zinc, potassium, and calcium supplementation. You need to consult your pet’s doctor first before using the Simplicef antibacterial treatment for your pet urinary tract infection or all other kinds of infectious diseases.

Simplicef Alternatives to Treat UTI in Dogs


There are more than 40 antibiotic drugs available in the market that are effective against a variety of infectious diseases for all breeds of dogs. I have mention Five (05) of them below which are effective against the urinary tract disease including bladder infection, kidney infection, urethra infection caused by bacteria, and are best alternatives to Simplicef film-coated tablets (by Zoestis Pharmaceuticals).
  • Amoxicillin
  • Enrofloxacin (brand name: “Baytril”)
  • Co-amoxiclav or amoxicillin trihydrate and clavulanic acid composition.
  • Smz Tmp (Sulfamethoxazole_Trimethorprim)
  • Marbofloxacin (brand name: “Zeniquin” FDA approved veterinary antibiotic drug)
 All antibiotics are prescription drugs. So, they all are only available on a veterinarian prescription only. You need a valid prescription to buy these drugs from online or your local drugstore. 
Categories: Simplicef

Doctor Xeeshan

Doctor Xeeshan

I am Doctor Xeeshan, located in Lahore, Punjab, Pakistan. In this blog, I am providing authentic information about dog breeds, diseases, medications, etc.


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