If you’re confused about some questions like “Can Humans take Simplicef for dogs?” or “Is Simplicef a human drug?”. Then, you’re at the right place, because today in the following short but brief piece of article, I have answered these questions. I will also clarify that “Why should humans not take veterinary drugs?” and the possible side effects or adverse reactions that may occur.


Basically, Simplicef is an FDA-approved, antibacterial drug, which contains a “Cefpodoxime proxetil” composition that kills bacteria by disrupting the bacterial cell wall. It’s a third-generation cephalosporin drug, a strong antibiotic for dogs, cats, and other small animals. 

Orelox tablets/liquid by Sanofi Aventis pharmaceutical contains the same ingredient “Cefpodoxime proxetil” and uses to treat bacterial infections in humans.

Simplicef film-coated Tablets are provided in 100mg and 200mg strengths. Zoetis pharmaceutical, a subsidiary of Pfizer Internationals, is a manufacturer of this drug. 

Can Humans Take Simplicef For Dogs?

NO! humans are not allowed to consume veterinary drugs that are used to treat different types of diseases and complications in animals. Although, Simplicef generic “Cefpodoxime proxetil” is approved to treat bacterial infectious diseases in both humans and animals. But the brand name “Simplicef (contains cefpodoxime)” is specially formulated for dogs, kittens, puppies, and other small animals. Simplicef 100mg and 200mg tablets are not suitable for humans. 

Most veterinary drugs come with a label “This drug is not suitable for humans”

Cefpodoxime is a broad-spectrum antibiotic that is highly effective against a broad range of diseases caused by bacteria. It can treat all types of soft tissue infections, wounds, abscesses, ear/nose, and eye bacterial infections, STDs (sexually transmitted diseases), and others not described here. 

Why Can’t Humans Use Veterinary Drugs?

Humans are not allowed to use animal-approved drug brands like Simplicef (by Zoetis pharma), Baytril, Albon, Rilexine, Clavamox, Clavacillin, and Convenia injection, etc. Here, I want to clarify that I am talking about drug brands, that are approved to treat diseases in animals. 

For example, Cefpodoxime proxetil is a chemical composition that is FDA approved to treat bacterial infectious diseases for both Humans and Animals.  

Simplicef contains “cefpodoxime proxetil”, but is specifically formulated to use in animals including canine and feline.

Side Effects OR Adverse Reactions

Another critical question is “What happens if humans use veterinary antibiotics?”.  As said before, humans are not allowed to use dog antibiotics. If a human is administered a veterinary-approved drug, then the following side effects may occur in reaction.

  • Vomiting
  • Nausea
  • Upset Stomach
  • Diarrhea
  • Abdominal cramps and pain.
  • Allergic reactions including skin rashes, irritation, itching, etc.
It’s hard to understand like “Why humans want to consume dog antibiotics?”. Because most veterinary drug brands are designed to use in animals. For instance, Clavamox (amoxicillin trihydrate_Clavunalate potassium) chewable tablets have pork-liver flavor and are specially formulated for feline and canine. On the other hand, Augmentin (amoxicillin trihydrate_clavunalate potassium) is the brand uses for humans. 
Both Clavamox (animals use) and Augmentin (for humans) contain the same generic “amoxicillin trihydrate and clavulanic acid”.  But the Clavamox brand is specified to use in animals. The Augmentin brand name is specified for humans.
Categories: Simplicef

Doctor Xeeshan

Doctor Xeeshan

I am Doctor Xeeshan, located in Lahore, Punjab, Pakistan. In this blog, I am providing authentic information about dog breeds, diseases, medications, etc.


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