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Can I use Simplicef (Cefpodoxime proxetil) for dogs allergic reactions?. This is a very important question to answer. So, in the following article, I decided to discuss How veterinary antibiotic drug helps to treat dog allergies?.


Antibiotic (anti means “against” and biotic means “bacteria“) are the chemical substances that are used to treat infectious diseases caused by bacteria (single: bacterium). Bacteria are very small, microscopic living organisms that cause bacterial infections.


The unnecessary use of antibiotic drugs may cause antibiotic resistance in the body that may be harmful. So, always consult a veterinarian, doctor, pharmacist, or physician before taking an antibacterial drug. Although, all antibiotics including Simplicef 100mg and 200mg tablets (by Zoetis pharmaceuticals) are prescription drugs and need a valid prescription to buy.

An allergic reaction is an automatic response against a foreigner substance by the body’s immune system.

Now I am going back to our primary topic that is Simplicef medication for dog allergies.


How Does Simplicef Tablets Treat Allergies In Dogs?

The answer is a little complicated because antibiotics do not treat allergies or allergic reactions directly but are used to treat the secondary bacterial infections caused by a primary allergic reaction.

Simplicef is the best FDA (Food and Drug Administration) approved third-generation cephalosporin (cephalosporin is the class of antibiotic drugs) for animals. It effectively kills bacteria by disrupting the bacterial cell wall. It prohibits the process of bacterial cell wall synthesis. 

A veterinarian may suggest Cefpodoxime proxetil, the active ingredient in Simplicef tablets, for the treatment of secondary bacterial infection in a dog. The treatment should not exceed the 30 days period. Usually, a dog may experience progress within the first 3 days of using this medication.   

But if you’re not experiencing progress by using cefpodoxime antibiotic medication within 3 days, it’s advised to re-visit your dog’s veterinarian and consult about the condition.

The recommended dose for cefpodoxime proxetil in dogs is from (minimum) 2.3mg/lb to (maximum) 4.5mg/lb. A veterinarian may suggest the ideal dosage plan for your pet after diagnosing the bacterial infection or the severity of the infection. 

Types of Allergies in Dogs

There are three major types of allergic reactions in dogs.

  • Food allergy
  • Environmental allergy
  • Insect allergy
All these types of dog allergies cause different types of symptoms like,

  • redness of skin
  • swelling or inflammation of different parts of the body (including eyelids, jaw, paws, face, etc)
  • sneezing
  • coughing
  • moderate to severe itching
  • hives
  • licking on the skin (including licking the paws, genital area, and other parts of the body)
  • runny nose
  • waterly and red eyes
  • vomiting
  • diarrhea
  • Upset stomach/gastrointestinal problems like gas, bloating, etc (due to food allergy)
  • difficulty in breathe

Food Allergy

A broad range of dog food brands is available in the market. But some of them may not be suitable for your pet because they may cause food allergy. Here, I am not discussing the taste or foods that your pet likes or does not. I am trying to say that there are certain types of foods that a dog may like to eat but its body responds differently.


The reasons for food allergies may be different. A dog whose body is hypersensitive to any of the food ingredients may cause allergic reactions in the body.  


Food allergy in a dog may cause the following adverse reactions in the body.

  • Diarrhea
  • Abdominal pain
  • Upset stomach
  • Gas
  • Bloating
  • GERD (Gastroesophageal Reflux Disease)
  • Gastrointestinal bacterial infection
  • Fever
  • Loss of appetite (anorexia disease)
  • Swelling and inflammation of the face and other parts of the body (in rare cases)


Simply stop providing that kind of food that causes allergies in your dog. If you’re not aware of that food, the food allergic test would be formed for your pet by the veterinarian.

Simplicef (cefpodoxime proxetil) 100mg film-coated tablets may be used to treat bacterial infections in dogs including persistent diarrhea and other gastrointestinal (soft tissue) infections.

Antibiotics are used to treat secondary bacterial infections caused by food allergies in dogs.

Environmental Allergy

In this case, a foreigner substance like dust particles, pollen, mold, polluted air may cause allergies in dogs. Usually, it happens due to environmental changes and it may also define as the seasonal allergic reactions in pets.


However, changes in the environment may not be in your dog’s favor. Because it may cause environmental allergies in dogs.


A dog with environmental allergy may face the following adverse reactions;

  • Sneezing
  • Coughing
  • Runny nose
  • Itching
  • Redness of skin
  • Swelling and inflammation of eyelids, face, paws, genitals, or other parts of the body
  • Difficulty in breathe
  • Hives
  • Skin rashes
In this case, the chances of developing a secondary bacterial infection are very high. It’s because when a dog bites or scratches the body due to itching, rashes, rashes, etc, the bacteria may grow and develop a bacterial infection.


Anti-itching sprays and other topical lotions, creams, and powders are available in the market that provides instant relief. However, a veterinarian visit is essential if the dog’s situation is critical. 

A veterinarian may also suggest anti-allergy or anti-histamine medication. Antibiotics drugs (Simplicef) are used to treat secondary bacterial infections caused by scratching or persistent itching.

Insects Allergy

Flea’s and other insects present in a dog’s body may cause allergic reactions. It’s because flea’s saliva causes itching. 


The symptoms of insect allergies in dogs are the same as others.

  • Skin rashes
  • Swelling and redness on the skin
  • Constant itching
  • Scabies
  • Hives
The chances of secondary bacterial infections are always high in the case of insect allergies. Simplicef (cefpodoxime proxetil) is a third-generation cephalosporin drug used to treat a broad range of bacterial infections caused by both gram-positive and gram-negative types of bacteria.


A veterinarian may suggest anti-allergic oral medication for your dog or may prescribe anti-itching sprays/lotions/creams to minimize symptoms. If a secondary bacterial infection has developed, then a veterinarian may suggest antibiotic treatment. Simplicef or Cefpodoxime proxetil antibiotic medication is advised to use for at least 3-7 days or by the recommendation of a veterinarian. 

The recommended dose of Cefpodoxime proxetil tablets varies from a minimum dose of 2.3mg/lb to a maximum of 4.5mg/lb for dogs.


At last, Antibiotic drugs do not treat allergies in dogs but they are used to treat secondary bacterial infections that may develop through scratching, biting, or licking the body parts. Simplicef is a broad-spectrum antibacterial medicine that can be used to treat a variety of infectious diseases caused by bacteria (single: bacterium).
Categories: Simplicef

Doctor Xeeshan

Doctor Xeeshan

I am Doctor Xeeshan, located in Lahore, Punjab, Pakistan. In this blog, I am providing authentic information about dog breeds, diseases, medications, etc.


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