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This article explains that whether “Is it necessary to give Simplicef (Cefpodoxime proxetil) tablets with food or not?” It’s a veterinary antibiotic drug that is used to treat a broad range of bacterial infections in dogs, cats, and almost all small animals. 

Simplicef Tablets are available in two strengths, 100mg, and 200mg respectively. They contain an active ingredient “Cefpodoxime proxetil” which is a broad-spectrum, third-generation cephalosporin, that treats all types of bacterial diseases caused by gram-positive and gram-positive bacteria. 


Cefpodoxime works against bacteria that contain a cell wall. Because they kill bacteria by disrupting the bacterial cell wall. Cephalosporins including cefixime, cefuroxime, cefepime, cefprozil, etc are not effective against bacteria who lack a cell wall, e.g, Cytoplasmic bacteria.

Cefpodoxime Proxetil With OR Without Food

So, get back to our primary question, “should Simplicef for dogs be given with food or not?“. Simplicef (cefpodoxime proxetil) for dogs may be given with or without food. It’s not necessary to give cefpodoxime with food. However, in some dogs, Simplicef antibiotic tablets may cause stomach upset when given on an empty stomach.

So, to avoid an upset stomach, it’s recommended to give Simplicef antibiotic medication to canine and feline with food. There is not a huge difference in the absorption of cefpodoxime proxetil (in a dog body) when it’s given with food or an empty stomach.

Adverse Reactions Of Taking Simplicef On An Empty Stomach

However, it is not necessary that cefpodoxime proxetil will show side effects and adverse reactions when given on an empty stomach. Antibiotics are hard on the stomach. So, it’s advised that take this medication for your dog on a full stomach to avoid abdominal problems. 

A dog may get the following unwanted consequences when taking an antibiotic drug on an empty stomach.

  • Abdominal Cramps
  • Upset Stomach
  • Lethargy 
  • Vomiting
  • Diarrhea
  • Nausea
  • Abdominal Pain
  • GERD (gastroesophageal reflux disease)
  • Gas 
  • Bloating

Simplicef Efficacy With and Without Food

A dog may take cefpodoxime with or without food because it does not make a huge difference in the absorption of this drug in the body. 

The recommended dose of cefpodoxime proxetil for dogs is between 2.3mg per one pound to 4.5mg per one pound. A vet may suggest the ideal dose plan after diagnosing the type of infection. This is a prescription drug and is not available without a vet prescription. 

If anyone of you has any further related queries then feel free to ask me. You can comment below this article or mail me. 
Categories: Simplicef

Doctor Xeeshan

Doctor Xeeshan

I am Doctor Xeeshan, located in Lahore, Punjab, Pakistan. In this blog, I am providing authentic information about dog breeds, diseases, medications, etc.


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