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Zoetis is the world’s most famous company that is providing great value in the field of veterinary medicine, especially for pets and dogs. Simplicef Tablet, available in 100mg and 200mg dosage, is one of Zoetis products.

In the following article, I would explain a well-known question, WHAT DOES SIMPLICEF TREAT IN DOGS? But before I started to inform you about Simplicef antibiotic benefits for dogs. You must be informed, What is it?.


How Simplicef WORKS for Dogs?

Simplicef is the trademark of Zoetis Pharmaceuticals Company. It contains Cefpodoxime Proxetil, a chemical compound, a third-generation, most cephalosporin. Don’t get confused about the term ‘cephalosporin’. Because cephalosporin is a class of antibiotic which has a list of best antibiotic for dogs ear infection, skin infections, respiratory tract infection, and all kind of other infectious diseases. 

Some antibiotics like metronidazole work by stopping the growth or duplication of bacteria in the body. But cephalosporin, third-generation, antibiotics work by direct killing bacteria in your dog’s body. They have the ability to fight all kinds of gram-positive and gram-negative bacterias. 

What Does Cefpodoxime Proxetil Treat in Dogs?

Simplicef (Cefpodoxime Proxetil) is a broad-spectrum antibiotic. It treats a variety of gram-negative and gram-positive bacteria like staphylococcus bacteria (causes staph infection in dogs), streptococci bacteria, pneumococci bacteria, etc.

These harmful germs cause different types of deadliest infections in dogs.  But you don’t need to worry about them, because Simplicef antibiotic has the ability to treat these infectious diseases very sufficiently and effectively.

Simplicef for Dogs Uses

Simplicef Treats the following infection in common;

  • It’s the FDA-approved drug to treat skin infections in dogs.  Skin infections in dogs like Staph infection may cause some serious problems for your pet if lets untreated.
  • For UTI (Urinary tract infections)
  • For Bladder infections
  • For upper respiratory tract infections
  • For your dog’s ear infections
  • For  nose and eyes infections
  • Simplicef treats kennel cough in dogs

 As said before, it’s a cephalosporin antibiotic that may be used in various types of infectious diseases. Your dog’s Veterinarian doctor first diagnoses the type and condition of infection then may suggest a proper Simplicef dosage for your dog. 

Simplicef Overdose

It is suggested to take a single dose of 5mg to 10mg Simplicef (cefpodoxime) per one-kilogram body weight for your pet. Your dog’s doctor may suggest the right dose for your dog by observing the condition. 

Do not overdose on the drug because it may cause some other life-threatening problems for your dog. Simplicef overdose may make your dog seriously ill. In case of overdosage, immediately seek medical help for your pet.

Simplicef Self-Treatment / Home Treatment

Cefpodoxime proxetil is not an over-the-counter drug for dogs. It’s a prescription drug, that can only be sold under a registered doctor, or veterinarian. Don’t try to use this drug on your own. Because it may cause some life-shortening side effects like;

  • Drowsiness
  • Sleepiness
  • Vomiting
  • Nausea
  • Serious Abdominal Pain
  • Fever
  • Dry Mouth
  • Rashes on the skin, etc

Simplicef Treatment Warnings and Precautions



Dogs antibiotic SIMPLICEF contains the active ingredient “CEFPODOXIME PROXETIL“. Never use this antibiotic if your dog is hypersensitive to this drug or any other cephalosporin antibiotic like Cephradine, Cefuroxime, Cefaclor, Cefadroxil, cephalexin, cefepime, ceftriaxone, or cefazolin, etc.

Categories: Simplicef

Doctor Xeeshan

Doctor Xeeshan

I am Doctor Xeeshan, located in Lahore, Punjab, Pakistan. In this blog, I am providing authentic information about dog breeds, diseases, medications, etc.


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